In this study, the antioxidant content of blood in the human subjects (measured by ORAC) increased by an average of 32%. This significant increase was attributable to the bioavailability and synergy of Pomella® Pomegranate Extract.

BEHIND POMELLA®

​THE POMELLA® SECRET: A DIFFERENT RESEARCH APPROACH

The approach to developing Pomella® Extract was quite visionary. Flying in

the face of the status quo for nutritional product development, the evolution

of Pomella in university research was not driven by business interests or cost,

but by what offers superior bioactivity and bioavailability. Pomella® is the

culmination of a complex research process that compared dozens, if not

hundreds, of different forms of pomegranates in various antioxidant and

bioavailability models. 

The Secret:
Not Much of a Secret

Nature has known this unique formula for ages, in the form of the natural

polyphenolic profile of pomegranate fruit. Yet there is a bit of patented magic

preserving the punicalagins as part of the natural spectrum of the pomegranate.


The most active pomegranate extract from the pomegranate research contained the ‘natural spectrum’ of polyphenols from the fruit – including the potent punicalagins, the top antioxidants behind the fruit’s scavenging power.

Additionally, a university study published in the Journal of Agricultural Food and Chemistry showed Pomella Extract to be one of the first pomegranate extracts to be detected in the bloodstream, where it also significantly increased the antioxidant capacity of blood from human volunteers.

Proprietary and published research shows that Pomella® maximizes the synergistic and additive effects of pomegranate. However, the research doesn’t stop there. The clinical data distinguishing Pomella as the ‘Gold Standard’ of pomegranate extracts continues. 


ONGOING GLOBAL RESEARCH INITIATIVES

Continued efforts are being made to validate Pomella Extract. Clinical trials are both NIH and privately funded.


If you are interested in learning more about our research, or are interested in conducting research, please contact us!


The figure to the left shows the necessary “Health Benefit Cascade” of steps that have been evaluated on Pomella® Extract and pomegranate polyphenols, notably the punicalagins within the natural spectrum of the pomegranate. The Pomella Extract research program addresses a number of issues that have historically plagued substantiation and proof of efficacy for dietary supplements. These issues include a lack of knowledge of specific antioxidant pharmacokinetics, metabolism, and pharmacodynamics; a lack of achieving efficacious blood and organ concentrations; and inadequate study design.

In summary, Pomella® and the natural spectrum of pomegranate polyphenols have been shown highly potent on the molecular and cellular scales, and these activities, along with antioxidant synergy and bioavailability, have translated into efficacy on the systematic scale, including those involved in health benefits.

GUT BACTERIA MAKE POMEGRANATE METABOLITES THAT CROSS THE BLOOD BRAIN BARRIER

In a quest to stay healthy, many people are seeking natural ways to prevent neurodegenerative diseases. Recent studies show that pomegranate extract, which is a rich source of disease-fighting polyphenols, can help protect against the development of them. But researchers weren’t sure which molecules to thank. A team reports in ACS Chemical Neuroscience that the responsible compounds may be urolithins, which are made when gut bacteria break down the polyphenols in the extract.

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Please note that the physiological activity of the ingredient(s) described herein is supported by the referenced clinical trial report(s). Marketers of finished products containing the ingredient(s) described herein are responsible for determining whether claims made for such products are lawful and in compliance with the laws of the country in which they will market the products.​

POMELLA® HELPS IMPROVE CARDIO-METABOLIC HEALTH

Researchers with the Srikot Research Institute studied the effects of Pomella® Extract (from Verdure Sciences) in patients (20-60 years of age) with myocardial infarction in conjunction with regular prescribed medications. The study determined the effects of 300 mg/Pomella twice daily for 30 days on biomedical parameters HDL, total cholesterol, triglycerides, LDL, non-HDL cholesterol, serum homocysteine, hs-CRP, and OX-LDL as an add-on with regular medication showing improved antioxidant status of the blood biomarkers associated with cardiac health.

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BIOAVAILABILITY

BIOAVAILABILITY OF POMELLA® POMEGRANATE EXTRACT

Pomella® Pomegranate Extract was introduced with a very refreshing

primary benefit: it is bioavailable, and this bioavailability leads to tangible

health benefits. A groundbreaking human pharmacokinetic study

(The Pomella® Absorption Study) was one of the first of its kind to show

a pomegranate extract is bioavailable in humans.

With very few exceptions, a substance must be bioavailable in order to

achieve tangible benefits in the body. Bioavailability means that a

phytonutrient is able to reach the bloodstream, where it can reach target

tissues. If it does not reach the bloodstream, it simply passes through and

out the other side – a veritable wast. Many times, a phytonutrient’s

bioavailability is not taken into account when considering its activity.

The lack of absorption has been a downfall of pomegranate extracts,

generally speaking, because the daughter molecule of punicalagins, ellagic

acid, has not shown to be bioavailable. Yet, if punicalagins are preserved,

and enter the body intact, then they are able to release ellagic acid into

the bloodstream.

The proof is in the Pomella! In the graph, are the active Pomella Extract metabolites. This study is one of the first to detect ellagic acid in the bloodstream.


Since the Pomella® Absorption Study, the bioavailability of punicalagins has been extensively studied. In fact, metabolites of punicalagins have been detected in the body 48 hours after consumption. Additionally, metabolites of punicalagins have been found to accumulate in the body’s organs, where they can act to provide tangible health benefits.

MECHANISTIC


POMELLA® POMEGRANATE EXTRACT FOR OPTIMAL CARDIOVASCULAR HEALTH
Pomegranate has been shown to exhibit greater antioxidant properties than green tea, red wine, blueberry juice, and others. While much research has been published on the connection between dietary polyphenols, antioxidant activity, and cardiovascular benefits, pomegranate may offer more than your average antioxidant.

As a scavenger of free radicals in the bloodstream, punicalagins and natural spectrum pomegranate polyphenols help regulate the degree of oxidation of proteins, macrophages, lipoproteins, and vascular endothelial cells. Punicalagins and pomegranate polyphenols also assist in the regulation of several enzymes that control vessel dialation (via nitric oxide) and promote overall endothelial health. The end result maximizes healthy blood flow and circulation, crucial keys in maintaining optimal cardiovascular health.


POMELLA® POMEGRANATE EXTRACT FOR ORAL AND DENTAL HEALTH
The importance of oral health, and its effects on overall health has recently been the focus of epidemiological studies. Only recently have researchers discovered that the same properties of pomegranate offering health benefits inside the body are the same properties offering health benefits for oral health.

Antioxidants seem to be a dime a dozen these days. Everyone claims to be the best; to prove it is no small feat.

The truly special thing about pomegranate is that it is one of just a few antioxidants that are proven to be more than just antioxidants. Pomegranate also has wide-ranging effects on inflammatory modulation, bacterial growth inhibition, and endogenous antioxidant enzyme systems such as superoxide dismutase (SOD).

Coincidentally, oral antioxidant status, oral inflammation, and bacterial counts are three main determinants of good oral health. Pomella® is shown to work in a US conducted clinical study, using a three pronged attack to promote oral health  – including potent antioxidant, inflammatory

modulating, and antibacterial actions. 


POMELLA® POMEGRANATE EXTRACT FOR SKIN HEALTH
When cells age, they lose the ability to do what they do best: regenerate and keep the function that keeps them from being old. The skin organ, being the body’s largest organ, is no exception to the aging paradigm. Its cells act in very much the same way as the rest of the body’s organs. Except the skin is even more susceptible to environmental factors such as UV radiation, which is a major part of sunlight exposure.

Sunlight, specifically the ultraviolet (UV) portion of sunlight, has some beneficial effects on people, such as promoting the body’s manufacture of Vitamin D. However, UV radiation is a double-edged sword because it also promotes skin aging in a multitude of ways.

UV-induced skin aging involves a multifaceted, complex process. Upon exposure to high doses or extended periods of UV, the following negative effects are repeatedly observed (and are often used as positive controls to determine the effects of skin aging): intracellular antioxidant activity is significantly decreased and reactive oxidative species (ROS) are significantly increased. A whole basket of related inflammatory up-regulating effects are also observed, such as increased cell death and increased activity of collagenases, which are the enzymes that destroy collagen – the structural fiber that keeps skin looking supple and youthful.

While prior studies show potential effects of pomegranate for skin health, many of these are performed at very high concentrations on crude extracts that have not been analyzed using adequate analytical methodology.

Pomella, however; is one of the first standardized extracts to show dose-dependent effects on a number of skin health promoting properties, and our dedication to its research and chemical analysis, maximizes consistency and speaks to this.

Furthermore, in a published, peer reviewed study on Pomella Extract, statistically significant increased UV-induced cell death, ROS, and collagenases (and statistically significant decreases in intracellular antioxidant capacity as determined by intracellular ORAC) were dose-dependently reversed by low concentrations of Pomella®.

In the same study, also observed were up-regulating effects of Pomella on the highly researched sirtuin SIRT1 – the renowned ‘longevity gene’. Since Pomella® has proven its bioavailability and absorption into the body, it may be an appropriate candidate for this type of longevity research. Ongoing research exploring the effects of Pomella Extract on the life extension sirtuin gene made famous by research on resveratrol is ongoing.

aNTIOXIDANT


POTENCY: BEYOND THE TEST TUBE - ORAC
Pomella® Extract has undergone extensive antioxidant testing, including ORAC, at multiple

independent labs and has been consistently found greater than 5000μmol TE/gram.

Additionally, Pomella is voluntarily participating in an ongoing ORAC single-lab validation

program to determine if the currently widely accepted method for ORAC is fit for its

intended purpose, as it is widely considered a quantitative estimation method.

However, ORAC, even if it passes analytical validation, measures only one type of

antioxidant activity – that of oxygen radical absorbance. Since the body contains many

types of free radicals aside from oxygen radicals, an appropriate antioxidant testing

program also includes measuring with other types of methods such as TEAC, FRAP, and

DPPH.

These antioxidant assays do not mean an antioxidant is able to be absorbed by the body.

This is one potential reason why there are so many ‘powerful’ antioxidants out there with

so few positive clinical research outcomes reported.


Pomella® Extract, in a published clinical study, has shown it significantly increases human plasma ORCA by an average of 32% after consumption. This means that it is not only a powerful antioxidant in the test tube, but is also a powerful antioxidant where it matters – in the body. This is how Pomella is able to translate into tangible health benefits.


ANTIOXIDANT SYNERGY OF POMELLA® POMEGRANATE EXTRACT
Synergies are found when the overall effect is often greater than the sum of

its parts. While punicalagins are responsible for the bulk of the activity of

pomegranate polyphenols, it is the preservation of the natural polyphenolic

ratio, or natural spectrum, which has been shown most potent and

bioavailable.

A comparison of natural spectrum pomegranate polyphenols to its purified

compounds “illustrated the multifactorial effects and chemical synergy of the

action of multiple compounds compared to single purified active ingredients.”

This synergy may also explain why pomegranate tops the list of all

antioxidant-rich beverages and why Pomella tops the list of several different

antioxidant assays, and is several fold more active in LDL oxidation assays

than pure ellagic acid.


Verdure Sciences, Longvida (US Patent 9192644, EP Patent 1993365; additional patents pending), Bacognize, Calzbone, Pomella (US Patents 7638640, 7897791, and 7919636; EP Patent 1734949; additional patents pending), Tinofend, and WokVel are registered trademarks of Verdure Sciences, Inc. Cinnagest,  Factor21, Lutevida, Rejuna, Thymocid, Gingerize, VBATS, VerdeMedica, SLP, and SLCP are trademarks of Verdure Sciences, Inc. All Rights Reserved. © 2016 Verdure Sciences.

HEALTH BENEFITS

​HEALTH BENEFIT CASCADE OF POMEGRANATE POLYPHENOLS AND POMELLA® EXTRACT

Pomegranate, specifically Pomella® Extract, has been featured as a model for clinical validation of dietary supplements for health benefits. For example, not only has Pomella shown potent activity in molecular-based in vitro studies such as ORAC, but it also increased ORAC of human plasma after consumption. An antioxidant can be a superstar in a test tube, but if it does not absorb into the bloodstream, then clinical efficacy is highly improbable.

latest research & news

These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.

SELECTED REFERENCES


​ANTIOXIDANT
Pomegranate extract modulates processing of amyloid-β precursor protein in an aged animal model. Ahmed AH et al. 2014, Current Alzheimer Research, 11.


Pomella® inhibits formation of markers responsible for oxidative stress: Advanced Glycation Endproducts (AGEs)

A 2014 University of Rhode Island, Kingston, shows that Pomella® phenolics inhibit the formation of a biologically relevant oxidative stress marker called Advanced Glycation Endproducts, or AGE.

Liu W, Ma H, Frost T, Yuan T, Dain JA, Seeram NP. Pomegranate phenolics inhibit formation of advanced glycation endproducts by scavenging reactive carbonyl species. Food and Function. 2014. 5: 2996-3004.

Pomella® found most potent antioxidant among pomegranate extracts.

UCLA study published in the Journal of Agricultural and Food Chemisty showed Pomella® ranked highest in antioxidant activity across a number of assays including ORAC, TEAC, FRAP, and DPPH, compared to 26 other antioxidant products.

J Agric Food Chem. 2014. 62: 4313-4321.

Comparison of antioxidant potency of commonly consumed polyphenol-rich beverages in the United States. J Agric Food Chem. 2008 Feb 27. 54(4) 1415-22. EPub 2008 Jan 26.

Safety and antioxidant potency of a pomegranate ellagitannin-enriched polyphenol dietary supplement in overweight individuals with increased waist size. J Agric Food Chem. 2007 Nov 28. 55(24): 10050-4. EPub 2007 Oct 30.

Absorption, metabolisim, and antioxidant effects of pomegranate (Punica granatum L) polyphenols after ingestion of a standardized extract (Pomella® Extract) in healthy human volunteers. J Agric Food Chem. 2006 Nov 15. 54(23): 8956-61.


BIOAVAILABILITY
Pomegranate juice and extracts provide similar levels of plasma and urinary ellagitannin metabolites in human subjects. J Med Food. 2008 Jun. 11(2): 390-4.

Absorption, metabolisim, and antioxidant effects of pomegranate (Punica granatum L) polyphenols after ingestion of a standardized extract (Pomella® Extract) in healthy human volunteers. J Agric Food Chem. 2006 Nov 15. 54(23): 8956-61.

Pomegranate juice ellagitannin metabolites are present in human plasma and some persist in urine for up to 48 hours. J Nutr. 2006 Oct. 136(10): 2481-5.

Beware of pomegranates bearing 40% ellagic acid. J Med Food. 2006 Spring. 9(1): 119-22.

Bioavailability of ellagic acid in human plasma after consumption of ellagitannins from pomegranate (Punica granatum L) juice. Clinica Chimica Acta. 2004 Oct. 348(1-2): 63-8.• Evaluation of the bioavailability and metabolisim in the rat of punicalagin, an antioxidant polyphenol from pomegranate juice. Eur J Nutr. 2003 Jan. 42(1): 18-28.


MECHANISTIC
Pomegranate’s neuroprotective effects are mediated by urolithins, its ellagitannin-gut microbial derived metabolites. ACS Chem Neurosci. 2015 Nov 11. A-H.

• Inhibitory effects of polyphenol punicalagin on type-II collagen degradation in vitro and in vivo. Jean-Gilles D et al. Chem-Bio Inter. 2013 Jun 20. 205: 90-99. EPub 2013 Jul 2.

The antiplaque efficacy of pomegranate mouthrinse. Quintessence Int. 2011 Jan. 42(1): 29-36.

Pomegranate extract mouth rinsing effects on saliva. DiSilvestro RA et al. Phytother Res. 2009. 23: 1123-1127. EPub 2009 Jan 23.

Pomella®: safety assessment of pomegranate fruit extract: acute and subchronic toxicity studies. Food Chem Toxicol. 2008 Aug. 46(8): 2728-35. EPub 2008 May 4.

Protective effects of standardized pomegranate (Punica granatum L) polyphenolic (Pomella® Extract) in ultraviolet-irradiated human skin fibroblasts. J Agric Food Chem. 2008 Aug 22.

Macrophage paraoxonase 2 (PON2) expression is up-regulated by pomegranate juice phenolic antioxidants via PPAR gamma and AP-1 pathway activation. Atherosclerosis. 2007 Dec. 195(2): 313-21. EPub 2007 Feb 12.

The influence of pomegranate fruit extract in comparison to regular pomegranate juice and seed oil on nitric oxide and arterial function in obese Zucker rats. Nitric Oxide. 2007 Aug. 17(1): 50-4. EPub 2007 May 5.

• Pomegranates for the prostate and the heart: seeds of hope. Harv Med Health Watch. 2007 Apr. 11(9): 4-5. No Abstract Available.


Effects of a pomegranate fruit extract rich in punicalagin on oxidation-sensitive genes and eNOS activity at sites of perturbed shear stress and atherogenesis. Cardiovasc Res. 2007 Jan 15. 73(2): 414-23.

patented pomegranate extract

standardized to punicalagins.

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