POMELLA® Extract was introduced with what was at the time a very refreshing main benefit: that it is bioavailable, and this bioavailability leads to tangible health benefits. A groundbreaking human pharmacokinetic study (The POMELLA® Absorption Study) was one of the first of its kind to show a pomegranate extract is bioavailable in humans.

 

With very few exceptions, a substance must be bioavailable in order to achieve tangible benefits in the body. Bioavailability means that a phytonutrient is able to reach the bloodstream, where it can reach target tissues. If it does not reach the bloodstream, it simply passes through and out the other side—a veritable waste. Yet too often a phytonutrient’s bioavailability is not taken into account when considering its activity.

 

The lack of absorption has been one downfall with pomegranate extracts—since the ‘daughter’ molecule of punicalagins, ellagic acid, has not been shown to be bioavailable. Yet, if punicalagins are preserved, and enter the body intact, then they are able to release ellagic acid into the bloodstream.

 

The proof is, well, in the POMELLA®. Below shows the active POMELLA® Extract metabolites. This study is one of the first times ellagic acid has been detected in the bloodstream.

 

 

 

 

Since the POMELLA Absorption Study, the bioavailability of punicalagins has been extensively studied. In fact, metabolites of punicalagins have been detected in the body 48 hours after consumption. Additionally, metabolites of punicalagins have been found to accumulate in the body’s organs, where they can act to provide tangible health benefits.

 

How does POMELLA® Extract compare? Check out the Antioxidant Synergy of POMELLA® for one comparison.